Autoimmune dermatoses are a diverse group of chronic skin disorders in which the immune system mistakenly attacks components of the skin, leading to inflammation, tissue damage, and impaired skin function. These conditions result from a breakdown in immune tolerance and are influenced by genetic predisposition, environmental triggers, and dysregulated cytokine networks. Common immunopathological features include the presence of autoantibodies, proinflammatory cytokines, and immune cell infiltration. Effective management of autoimmune dermatoses requires targeted suppression of the abnormal immune response. Current treatment strategies include topical or systemic immunosuppressants, phototherapy, and biologic therapies that block key inflammatory pathways such as TNF-α, IL-17, and Th2 cytokines. These interventions aim to reduce inflammation, control symptoms, and enhance patients’ quality of life.