Syngeneic Models

Syngeneic Models

Syngeneic models are tumor models in which murine tumor cells are transplanted into genetically identical or immunocompetent mice (e.g BALB/c or C56BL/6) of the same inbred strain. These models maintain an intact immune system, making them ideal for studying tumor-immune interactions and evaluating immunotherapy agents.

Key Features of Syngeneic Models

  • Immunocompetent: Host immune system remains functional.
  • Rapid tumor formation: High tumor take rates and reproducibility.
  • Cost-effective & scalable for preclinical screening.
  • Ideal for immunotherapy studies, including checkpoint inhibitors, vaccines, and adoptive cell transfer.
Cancer TypeCell LineBackgroundEngineered Human or Mouse TargetAvailability
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)Available
ColorectalCT26BALB/chCD47(Tg)-mCD47(KO)Available
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO)Available
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO)Available
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD39(Tg)-mCD39(KO)Available
ColorectalCT26BALB/chNectin4(Tg)-mNectin4(KO)Available
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)Available
ColorectalCT26BALB/chROR1(Tg)-mROR1(KO)Available
ColorectalCT26BALB/chPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available (Cell only)
ColorectalCT26BALB/chCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available (Cell only)
ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)Available
ColorectalMC38C57BL/6hCD47(Tg)-mCD47(KO)Available
ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO)Available
ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)Available
ColorectalMC38C57BL/6hPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available (Cell only)
ColorectalMC38C57BL/6hCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)Available (Cell only)
BreastEMT6BALB/chPDL1(Tg)-mPDL1(KO)Available
BreastEMT6BALB/chCD39(Tg)-mCD39(KO)Available
MelanomaB16F10C57BL/6hPDL1(Tg)-mPDL1(KO)Available
LiverH22BALB/chPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO)Available
LiverH22BALB/chPDL1(Tg)-mPDL1(KO)Available
ColorectalCT26BALB/cNoneAvailable
LiverH22BALB/cNoneAvailable
Breast4T1BALB/cNoneAvailable
BreastEMT6BALB/cNoneAvailable
LymphomaA20BALB/cNoneAvailable
LymphomaMPC-11BALB/cNoneAvailable
LymphomaJ558BALB/cNoneAvailable
B lymphocyteBcL1 clone 5B1bBALB/cNoneAvailable
RenalRENCABALB/cNoneAvailable
LeukemiaWEHI-3BALB/cNoneAvailable
Embryonal CarcinomaNFPEBALB/cNoneAvailable
ColorectalMC38C57BL/6NoneAvailable
LungLLC1C57BL/6NoneAvailable
PancreasPAN02C57BL/6NoneAvailable
MelanomaB16F0C57BL/6NoneAvailable
MelanomaB16F1C57BL/6NoneAvailable
MelanomaB16F10C57BL/6NoneAvailable
BreastMMT 060562C57BL/6NoneAvailable
BreastE0771C57BL/6NoneAvailable
LymphomaYAC-1C57BL/6NoneAvailable
LymphomaE.G7-OVAC57BL/6NoneAvailable
LymphoblastC1498C57BL/6NoneAvailable
B lymphocyteHOPC 1F/12C57BL/6NoneAvailable
ProstateRM-1C57BL/6NoneAvailable
SarcomaSal/NTBDNoneAvailable
BladderMB49TBDNoneAvailable

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