Oncology Models
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- Oncology Models
Oncology Models
At Axiocell, we offer a comprehensive suite of human xenograft models, including both Cell-Derived Xenograft (CDX) and Patient-Derived Xenograft (PDX) models, to support preclinical cancer research and drug development.
Cell-derived Xenograft (CDX)
Transplantation of human tumor cell lines into immunodeficient NCG mice / CD34+ Humanized Mice
>> Most frequently used
Patient-derived Xenograft (PDX)
Implantation of cancer patient-derived tumor tissues into immunodeficient NCG mice / CD34+ Humanized Mice
>> Most Clinically relevant
Spontaneous Tumor Models
Genetically modified models to develop tumors naturally in an intact murine immune system
Syngeneic Models
Transplantation of murine tumor cell lines into wild-type mice or transgenic mice
Drug Resistant Models
Drug resistance induced by long-term drug exposure or genetic modification; ideal for investigating refractory and relapsed cancers
T-cell Engager Models
T-cell engagers are bispecific antibodies that redirect T cells to recognize and kill tumor cells by simultaneously binding to tumor antigens and CD3 on T cells
Integration with Humanized mice models with Human Immune System
To study tumor-immune interactions and evaluate immunotherapies, we offers humanized immune system mouse models. By reconstructing the human immune system in NCG mice using human PBMCs or CD34+ Hematopoietic stem cells, these models can be combined with CDX or PDX tumors to assess the efficacy of immune-based treatments.
Axiocell Biotech Sdn Bhd.
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