Human Immune System Mice
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- huPBMC-NCG-MHC-dKO
huPBMC-NCG-MHC-dKO
Type : PBMC Humanized Mice
Strain Number : T060123
Background Strain: NCG-MHC-dKO [T050886]
The huPBMC-NCG mouse model is established by transplanting Peripheral Blood Mononuclear Cells (PBMCs) from healthy donors into highly immunodeficient NCG mice with double knockout of murine MHC class I and II genes [NCG-MHC-dKO T050886] to create a human immune system-reconstituted model. The additional deletion of MHC I/II minimizes xenogeneic immune interactions, thereby reducing the severity of graft-versus-host disease (GvHD). Similar as conventional HuPBMC-NCG [T057056], this model enables rapid reconstitution of human T cells and is particularly suited for short-term studies involving T-cell-mediated immune responses, immuno-oncology research, and GvHD drug evaluation. The MHC-dKO background also improves experimental consistency and prolongs the survival window compared to conventional huPBMC-NCG model.
Preclinical anti-tumor efficacy studies and safety evaluation
Long-term efficacy evaluation
Fig 1: A) Body weight, B) Survival Rate, C) GvHD Scoring, D) Immune Profile of huPBMC-NCG-MHC-dKO mice post injection of human PBMC.
- Sprent J, Webb SR: Function and specificity of T-cell subsets in themouse. Adv Immunol 41:39—133, 1987
- Madsen L, et al., Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10338-43
- Brehm, Michael A., et al. “Lack of acute xenogeneic graft-versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.” The FASEB Journal (2018): fj-201800636R.
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