Autoimmune Nephropathy
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- Autoimmune Diseases
- Autoimmune Nephropathy
Autoimmune Nephropathy
Autoimmune Nephropathy refers to a group of kidney diseases caused by the body’s immune system mistakenly attacking the kidneys. These conditions can lead to inflammation and damage to the structures of the kidneys, impairing their function.
Model:
B6-hBAFF LN model
Features:
Lupus nephritis
B cell activation
Complement pathway
(clasiccall/alternative)
lgA/lgG/C3 deposition
Model:BSA+CCI4+LPS induced lgAN model
Features:
lgAN model
lgA / lgC deposition
Complement pathway
(lectin/alternative)
Model:
Humanized C3 Mouse
Features:
Accelerated C3
Glomerulopathy
Alternative complement
pathway
C3 deposition
Model:
CDH-KO mouse induced by NTS
Features:
C3 Glomerulopathy
Complement pathway
Model:
CBSA induced MN model
Features:
MN model
lgG deposition
Complement pathway
classical
BSA+CCl4+LPS induced IgA nephropathy mouse model
This model closely mimics the key pathological features of human IgA nephropathy through a combination of BSA-induced immune complex formation, CCl₄-induced hepatic injury, and LPS-stimulated immune activation. It reliably induces mesangial IgA deposition, glomerular inflammation, elevated serum IgA levels, and proteinuria. This evidenced by increased mALB/CREA and UTP/CREA ratios which serve as hallmark indicators of renal damage. This model offers a robust and translational platform for investigating IgA nephropathy mechanisms and assessing potential immunomodulatory therapies.
Figure shows IgA deposition at Kidney after 4 weeks of LNP023 or Astrasentan treatment.
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