Systemic Lupus Erythematosus (SLE) Models
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- Autoimmune Diseases
- SLE Models
Systematic Lupus Erythematosus (SLE) Models
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by T and B cell dysregulation, leading to inflammation and organ damage. The production of antinuclear antibodies (ANA) triggers immune complex deposition and complement activation, affecting the skin, kidneys, joints, and heart.
Model:
B6-Trex1-KO
Pathogenesis:
cGAS-STING-IFNα
Model:
B6-hBAFF
Pathogenesis:
B cell Activated
Model:
BALB/c-Tlr7-p.Y264H
Pathogenesis:
pDC activation related
Model:
Pristane-Induced SLE
Pathogenesis:
Innate & Adaptive Immunity
Model:
TLR7 agonist Induced SLE in HSC-NCG-M
Pathogenesis:
Humanized Immunity
Model:
SLE patient derived PBMC induction
Pathogenesis:
Humanized Immunity
B6-Trex1-KO Mouse
Strain: C57BL/6JGpt-Trex1em1Cd1194/Gpt
Strain ID: T013987
The B6-Trex1-KO (knockout) mouse model lacks the Trex1 gene, which encodes a DNA exonuclease critical for preventing the accumulation of cytosolic DNA. Its deficiency leads to chronic activation of the type I interferon pathway and mimics autoimmune conditions such as Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus (SLE). This model is valuable for studying autoimmunity, innate immune sensing, and inflammation-related pathologies.
Survival Rate
Autoantibodies
Trex1-/- showed significantly increased Anti-dsDNA An
Organ Inflammation
Kidney: Inflammatory cell infiltration (black arrow); Bleeding (red arrow)
B6-hBAFF
Strain: C57BL/6JGpt-Tg(hBAFF)35/Gpt
Strain ID: T036794
The B6-hBAFF mouse model expresses human B cell-activating factor (BAFF) on a C57BL/6 background. BAFF is essential for B cell survival, maturation, and function, and its dysregulation is associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This model is ideal for evaluating BAFF-targeted therapies and studying human B cell biology in vivo.
Anti-dsDNA Abs and Immunoglobulins
Increased anti-dsDNA and serum lg Levels in B6-hBAFF Mice
Lupus Nephritis
B6-hBAFF mice show Lupus Nephritis in 25 weeks
Pristane induced SLE
Strain: BALB/c, C57BL/6, DBA
The pristane-induced systemic lupus erythematosus (SLE) model is a chemically induced autoimmune model in which a single intraperitoneal injection of pristane (a hydrocarbon oil) in mice. triggers lupus-like symptoms. These include autoantibody production (e.g., anti-dsDNA), immune complex deposition, glomerulonephritis, and chronic inflammation. This model closely mimics aspects of human SLE pathogenesis and is widely used for studying disease mechanisms and evaluating potential immunomodulatory treatments.
Elevation of serum Anti-dsDNA post 9 weeks of pristane injection in BALB/c, C57BL/6 or DBA female mice
For more information:
Humanized SLE Models
Strain: huHSC-NCG-M or NCG
- Evaluation of human-specific autoimmune responses such as Immune cell hyperactivity, autoantibody production, type I IFN signaling, cytokine and nephritis.
- B-cell depletion therapies e.g CD19, CD20, BAFF antibodies and CAR-T / CAR-NK cell therapies
- Interferon inhibitors
- Immune checkpoint modulators1
Humanized SLE model construction
Key Features
Mostly T cells only
Study period 14-21 days
Anti-dsDNA increased from 2-4 weeks
Highly Donor dependent
Proteinuria
Relatively complete set of human immune system
TLR agonist (4-6 weeks) Pristane (18-24 weeks)
Lupus nephritis (Mild to moderate)
For more information:
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