AxioCell Biotech - BALB/c-Nu (Nude Mice)

Immunodeficient Mice

IMMUNODEFICIENT MICE

BALB/c-Nu (Nude Mice)

Strain Name: BALB/cNj-Foxn1nu/Gpt
Strain Type: Mutation
Strain Number: D000521

STRAIN DESCRIPTION

BALB/c-Nude, also called nude mouse, is a strain carrying mutant Foxn1 gene (Foxn1nu ) and thus defective in thymic epithelium development and abnormal hair growth. Foxn1, encoded by Foxn1 (Forkhead box N1, also called Hfh11 or Fkh19) gene, is a transcription factor expressed in thymic epithelium. Foxn1 plays an important role in a wide range of biological and pathological process, such as immune response, tumor formation, metabolic reaction and senescence. Although appeared hairless, these nude mice are born with functional but faulty hair growth follicles. Hair growth cycles and patterns are evident, but the faulty follicles fail to allow the hair to erupt. Homozygous nude mice lack functional T-cells and are partially deficient in B cells, thus can be used as an immune deficient mouse model for rapid growing tumour without full immune rejection.

APPLICATIONS

Dermatologic Study

Endocrine Deficiency Research

Immune & Inflammation Research

Athymism Research

Xenograft & Cancer Research

BASIC INFORMATION

Strain Name

BALB/cNj-Foxn1nu/Gpt

Strain Number

D000521

Official Symbol

Foxn1

Strain Strategy

D000521.BALB_c-Nude strain info.pdf

Official Full Name

forkhead box N1

Also Known As

D11Bhm185e,Fkh19,HFH-11,Hfh11,Whn,nu,nude

NCBI Number

15218

MGI Number

102949

Chromosome

11 Strain Background

[N000020] BALB/cJGpt

Modification Type

Spontaneous Mutation

Inventory Status

Live Animal, Cryopreserved

Health Status

Specific pathogen free (SPF)

Publications

1.NIR-II Fluorescent Thermophoretic Nanomotors for Superficial Tumor Photothermal Therapy. Advanced materials (Deerfield Beach, Fla.) (2025)

2.FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma. Theranostics (2025)

3.STX17-DT facilitates axitinib resistance in renal cell carcinoma by inhibiting mitochondrial ROS accumulation and ferroptosis. Cell death & disease (2025)

4.Targeting USP1 Potentiates Radiation-Induced Type I IFN-Dependent Antitumor Immunity by Enhancing Oligo-Ubiquitinated SAR1A-Mediated STING Trafficking and Activation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025)

5.Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation. Theranostics (2025)

6.Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma. Cell death and differentiation (2025)

7.Enzymatically responsive nanocarriers targeting PD-1 and TGF-β pathways reverse immunotherapeutic resistance and elicit robust therapeutic efficacy. Journal of nanobiotechnology (2025)