Scleroderma
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- Autoimmune Diseases
- Scleroderma
Scleroderma
Systemic sclerosis (SSc), also known as scleroderma, is a rare autoimmune connective tissue disorder associated with increased morbidity and mortality. It is characterized by inflammation and autoimmunity, vasculopathy, and fibrosis of the skin and internal organs. To aid with your preclinical studies, GemPharmatech offers several validated SSc mouse models.
Model
BLM-induced SSc model (BALB/c-B6)
Feature
Pulmonary fibrosis
Skin fibrosis
Model
hIL23-induced BLM-induced SSc model (HSC-NCG-IL15)
Feature
Pulmonary fibrosis
Skin fibrosis
Suitable for broad spectrum immune drug
Model
HOCL-induced SSc model (BALB/c)
Feature
Skin fibrosis
For more information:
Bleomycin-Induced Mouse Model
The SSc model induced by Bleomycin (BLM) is a classic animal model used to evaluate the preclinical efficacy of drugs for treating SSc. We utilized Bleomycin (BLM) to induce a scleroderma mouse model in C57BL/6J, BALB/c, and HSC-NCG-IL15 mice.
The BLM-induced model strategy is shown in Fig.1A. After induction of B6 mice for 28 days, the dermal thickness of model group mice with BLM induction increased significantly (Fig.1B). Lung HE staining of the model group revealed inflammatory cells, alveolar cavity collapse, and hemorrhage – exudation of cellulosic material (Fig.1C). In the skin modeling area of the model group, the inflammatory cytokines increased significantly (Fig.1D).
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